Postdoctoral Fellow

City of Hope

Duarte, CA

Job posting number: #7058341

Posted: July 9, 2019

Application Deadline: Open Until Filled

Job Description

We are seeking a talented and motivated Postdoctoral Fellow to become a part of the multidisciplinary research team headed by Dr. Ajay Goel, who recently relocated to the City of Hope. His research is highly focused on understanding the interplay between genetic and epigenetic alterations in colorectal, pancreatic, gastric and esophageal cancers. One of the primary translational research goals is to develop novel diagnostic, prognostic, and predictive biomarkers for various gastrointestinal cancers, as well as study immune regulation and identify novel therapeutic targets (e.g. targeted therapies, immune checkpoint inhibitors) for various GI malignancies. Our multidisciplinary research group comprises of basic biologists, gastroenterologists, surgeons, oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia.

The projects will involve any/all of the following research focuses:
Exploration of cell-free DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal).
Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
Study the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in various GI malignancies.
Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers
Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells.
The role of tumor microenvironment, immune regulation and identification of various targeted therapies (e.g. immune checkpoint inhibitors) in GI cancers.
The role of exosomes as biological determinants, and exosomal cargo as disease biomarkers
Gut microbiome and its influence in gastrointestinal cancers
The ideal candidate will possess:
Relevant experience in cancer genetics and epigenetics.
Prior hands-on experience in developing cell-free DNA and RNA-based, liquid biopsy assays in cancers.
Preference will be given to individuals who had previous experience with microarray and next generation sequencing-based platforms (MiSeq, HiSeq, NovaSeq, RRBS, ChIP-Seq, MeDip etc.).
Strong background in biochemistry and/or molecular biology, as well as experience in identification and development of therapeutic targets in cancer.
Desire to grow and develop skills in order to become an independent Investigator
Possess excellent communication and writing skills
Enthusiastic and highly motivated
Able to think creatively and independently
Possess good organizational skills
Able to work independently and in a team environment

Basic education, experience and skills required for consideration:
A Ph.D. and/or MD/PhD degree in life or biomedical sciences, or a related discipline is required.
Evidence of first author peer-reviewed publications
Prior molecular, cancer biology and/or translational research experience and evidence of project development

Additional Information:
Curriculum Vitae and coordinates of three scientific mentors
A cover letter highlighting your research interests, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


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