Postdoctoral Fellow - Molecular Mechanisms of Myeloma

City of Hope

Duarte, CA

Job posting number: #7058342

Posted: July 9, 2019

Application Deadline: Open Until Filled

Job Description

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow to become an integral part of Pichiorri Lab, within the Division of Hematologic Malignancies and Stem Cell Transplantation Institute.

Our long-term goal is to elucidate the molecular mechanism(s) underlying the development of myeloma and the insurgence of mechanisms of acquired resistance upon treatments. As such, the successful candidate will participate in the investigation of microenvironmental, genetic and epigenetic changes associated with myeloma development, including but not limited to diabetes predisposition to cancer and small non coding RNAs using different myeloma mouse models, primary samples and in vivo correlative studies. With strong support from the department, one of the main goals is to foster the discovery of novel therapeutic targets for the treatment of myeloma and to develop specific Phase 1 trial for bridging the gap between basic science and clinical practice.

Basic education, experience and skills required for consideration:
A Ph.D. degree in biology, life or biomedical sciences, or a related discipline is required;
Experience in recombinant protein production for cellular drug high throughput screening, protein purification and protein-protein interaction;
Experience in DNA damage;
In vitro cell culture: human and mouse cells, leukemia, myeloma, cell transfections and drugs treatments;
Experience in mouse bone marrow transplant (BMT) and engraftment studies;
Experience with any of the animal cancer models: leukemia/myeloma or solid tumors (breast, prostate, liver);
Experience in multicolor flow cytometry, RNA, DNA isolation and preparation, QRT-PCR, Elisa assay, Western blot, IP techniques, Cloning and Luciferase assay.

Additional Information:
For more information about Dr. Pichiorri’s research, please visit: https://www.cityofhope.org/people/pichiorri-flavia.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


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