Postdoctoral Fellow - Charis Eng & Ying Ni Lab

Cleveland Clinic

Cleveland, OH

Job posting number: #7232896 (Ref:ccf20157187)

Posted: March 28, 2024

Job Description

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

The Charis Eng laboratory is seeking a highly motivated, self-driven postdoctoral research fellow for the Genomic Medicine Institute at Cleveland Clinic Lerner Research Institute. PTEN hamartoma tumor syndrome (PHTS) is molecularly defined as the presence of germline PTEN mutation. Why mutation of a single gene PTEN results in specific cancer risks and/or autism spectrum disorder (ASD) is unknown. The Eng lab seeks modifiers from genome seq which may help bifurcate cancer vs ASD clinical outcomes. The successful candidate will have demonstrated proficiency in bioinformatics, computational genomic epidemiology and/or data science.

This position will be co-advised by Dr. Eng (human genomicist) and Dr, Ni (computational biologist).

Principal Investigator: Charis Eng, MD, PhD; Ying Ni, PhD

Lerner Research Institute Department: Genomic Medicine Institute

Lab Research Topics:

Job Responsibilities:

  • Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
  • Identification and characterization of modifiers interacting with PTEN mutation
  • Integrative analysis of multi-omics data for feature selection
  • Provide clear, detailed and thorough progress reports


  • PhD or MD/PhD required
  • MD with relevant laboratory experience may substitute for PhD


  • English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

  • Previous experience in a research or academic setting.  Graduate student experience meets this requirement.
  • Scientific writing experience

Additional Preferred Qualities:

  • PhD required
  • Trained and proficient in bioinformatics, data science and or computational genomics
  • Highly motivated and self-driven individual with exemplary work-ethic and ability to promote team-spirit/collegiality

Physical Requirements:

  • Ability to perform work in a stationary position for extended periods
  • Ability to operate a computer and other office equipment
  • Ability to communicate and exchange accurate information
  • Ability to distinguish color
  • Manual dexterity to handle specimens and repair equipment
  • Ability to lift and transport equipment or specimens weighing up to 20 pounds
  • May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

  • PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

  • CV
  • Research statement
  • Three references (names and contacts)
  • All application materials should be submitted directly via email to Dr. Charis Eng at [email protected].

Keywords: Postdoc, Research, LRI, Genomic Medicine Institute, Omic modifiers, Germline PTEN mutation

Pay Range

Minimum hourly: $0.01

Maximum hourly: $333,340.26

The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.

By embracing and understanding the diversity EVERY ONE brings, Cleveland Clinic has created an inclusive culture that promotes innovation, growth, and new ideas. This has enhanced our ability to attract the best global talent to provide the best patient experience possible. Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities. Smoke/drug free environment.

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Job posting number:#7232896 (Ref:ccf20157187)
Application Deadline:Open Until Filled
Employer Location:Cleveland Clinic
United States
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